Medically reviewed by Deborah Lenchus, MSN, APRN · Last reviewed July 2026.
Cosmelan and Dermamelan are professional, in-office depigmentation methods for melasma and stubborn discoloration. They are among the most effective non-laser options for melasma — which matters, because melasma is easily worsened by heat and aggressive lasers. Here is how they compare.
How they are similar
Both start with an in-office mask applied by your provider, followed by a structured home-care phase. Both reduce excess pigment production rather than just bleaching the surface, and both require commitment and strict sun protection to succeed.
How they differ
Dermamelan is generally the more intensive, professional-strength method, often chosen for more resistant or extensive melasma. Cosmelan is a widely used, effective option that can be a strong first choice for many patients. The best fit depends on your melasma severity, skin type, and history.
Deborah’s Clinical Perspective
Melasma is a marathon, not a sprint — and the in-office mask is only half the job. What truly determines success is the home-care phase and relentless sun protection. I match the intensity of the protocol to how stubborn the melasma is, and I set honest expectations: we are managing a chronic condition beautifully, not “curing” it once. Done right, these protocols give some of the most satisfying pigment results in aesthetics.
FAQ
Which is stronger, Cosmelan or Dermamelan?
Dermamelan is generally the more intensive, professional-strength protocol, often used for more resistant melasma, while Cosmelan is an effective and widely used option.
Do these cure melasma?
Melasma is a chronic condition that is managed rather than cured. These protocols can dramatically reduce pigment, but maintenance and sun protection are essential.
Is this safer than laser for melasma?
For many patients, yes — depigmentation protocols avoid the heat that can flare melasma, making them a mainstay of melasma care.
Book a melasma consultation in Davie & Weston.