Melasma & Pigmentation (Cosmelan & Dermamelan)

It can be done any time, but fall and winter are ideal when sun is less intense. In sunny climates or summer, strict sun avoidance and a very high SPF such as mesoprotech melan 130 are essential.

Cosmelan is a two-step protocol: a single in-office mask session plus an at-home regimen, lasting about six months in total, depending on how severe the pigment is.

The biggest change appears a few weeks after the in-office mask, but that only clears surface melanin. Continuing the home phase is what regulates the pigment-producing cell (melanocyte) and prevents the spots from returning.

Stopping interrupts the treatment. The melanocyte stays overactive and the spot returns as skin renews. Skipping daily photoprotection also greatly raises the risk of the pigment coming back.

Yes. In the later months it can be paired with maintenance products such as melan tran3x to help prolong your results.

Yes, it is non-invasive. Just take extra care in the first few days after the mask — avoid pools, prolonged sun, and heavy sweating during the skin’s adaptation period.

Pigment can be visibly reduced, but it is a dynamic process, so a daily regulating depigmentation routine and year-round sun protection are essential to prevent repigmentation.

If you have ongoing triggers (hormones, pregnancy, sun, post-acne, etc.), keep a daily routine that combines a depigmenting product like melan tran3x with a high photoprotector such as melan 130 pigment control.

Used correctly under professional supervision, side effects are minimal. Expect temporary redness or irritation early on and mild peeling and sensitivity during the home phase, which resolve with the recommended home products.

Cosmelan is a depigmentation treatment, not a treatment for active acne, but it is effective on the dark marks acne can leave behind (post-inflammatory hyperpigmentation).

Both deliver excellent results. Cosmelan is an aesthetic treatment, while Dermamelan is a medical-grade, provider-supervised treatment with a newer patented formula designed for the most severe, resistant pigment, with results in about four months.

It is often called a peel, but it is more than that. Unlike a traditional surface chemical peel, Cosmelan is a multi-phase professional program that also works on the source of the pigment.

No. The skin renews gradually in a controlled way. After the in-office phase, expect mild redness and warmth that fade within 24 to 48 hours. During the home phase, slight flaking and some sensitivity are normal and ease with the recommended products.

Yes. It is a non-invasive topical treatment. It is important, though, to keep up the daily home regimen and to minimize sun exposure throughout.

Spots are very significantly reduced, but any area that had a spot always carries a tendency to return, so ongoing homecare and specific sun protection are essential to prevent repigmentation.

Ideally after summer, to avoid intense sun during treatment. Where sun is unavoidable, avoid direct exposure and use a hat and proper photoprotection.

Laser and peels only remove existing pigment and cannot prevent recurrence. Dermamelan both corrects and regulates — treating the cellular root of the problem and keeping melanin overproduction in check to help prevent the spots from coming back.

Minimal when used correctly under professional supervision. Expect temporary redness or irritation early and mild peeling and sensitivity in the home phase, which resolve with the recommended home products.

The most significant change comes within a few weeks of the in-office mask, but the full four-month protocol is needed to also regulate melanin overproduction for a lasting result.

It uses two exclusive patented complexes — (Syn)pigmentarget and Melaphennone — that work together to inhibit and reduce pigment production at the melanocyte, targeting even the most resistant spots.

It happens in two phases. First, we apply a professional-strength depigmenting mask in the office that you keep on for a set number of hours before removing it at home. Because the mask needs to stay on for several hours, Cosmelan and Dermamelan appointments are scheduled in the morning or very early afternoon — this ensures there is enough time for the mask to work and for you to remove it at home before bedtime. Second, you follow a guided home regimen that maintains and continues your results over the following weeks and months. That home step isn’t optional — it’s what turns a temporary fade into lasting, even tone.

Both are professional two-phase depigmentation systems by mesoestetic, and the main difference is intensity. Cosmelan is the versatile, widely used, hydroquinone-free option that fades melasma, sun spots, and uneven tone across all skin types with a gentler profile. Dermamelan is the more intensive, medical-grade protocol designed for more resistant, stubborn, or long-standing melasma. At your consultation, your nurse practitioner assesses your skin, its history, and your triggers to recommend the right protocol for you.

Expect some redness, flaking, and peeling for several days as your skin renews, similar to a peel. Diligent sun protection and following your home products exactly are essential — both for your results and because sun exposure is the main trigger for melasma returning.

Yes. It’s one of the reasons these systems are so widely used — they’re designed to work safely across all skin phototypes, including deeper complexions.

Melasma can’t be permanently cured, but it can be significantly reduced and kept under control with treatment plus ongoing sun protection and maintenance. That’s why we build a long-term plan rather than a one-off treatment.

Many people notice brightening within the first couple of weeks, with tone continuing to even out over the following months.

Plan for several days of redness and peeling. Most people schedule their treatment around their social calendar.

Melasma is chronic and needs a real plan, not a one-off treatment. With 20+ years of experience, our nurse practitioner builds a protocol around your skin and your triggers, so you’re managing pigmentation for the long term rather than chasing it.